Abstract
The discovery of ubiquitin conjugation to lysines and the role of K48-linked polyubiquitin in targeting substrates for proteasomal degradation was followed by revelation of non-degradative roles of ubiquitination and, more recently, of non-canonical covalent ubiquitin linkages. Here we summarize findings of the ever-expanding array of ubiquitin signals and their biological roles.
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Acknowledgements
This work was supported by a NIH grant GM130393 (C.W.) and fellowship CA271743 (S.R.).
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Rahman, S., Wolberger, C. Breaking the K48-chain: linking ubiquitin beyond protein degradation. Nat Struct Mol Biol 31, 216–218 (2024). https://doi.org/10.1038/s41594-024-01221-w
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DOI: https://doi.org/10.1038/s41594-024-01221-w
