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Just how big is the ubiquitin system?

Nature Structural & Molecular Biology volume 31, pages 210–213 (2024)Cite this article

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The modification of proteins with the small protein ubiquitin constitutes a Daedalian system of posttranslational modifications in every eukaryotic cell, which is often referred to as the ubiquitin code1. Here we consider the scale and complexity of the ubiquitin system in light of recent developments.

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Fig. 1: Types of ubiquitin linkages on proteins and other biomolecules.
Fig. 2: Overview of tools to study the ubiquitin code on proteins and other biomolecules.

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Acknowledgements

B.C.L. and D.K. are supported by National Health and Medical Research Council Investigator grants GNT2016268 (B.C.L) and GNT1178122 (D.K.).

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Authors and Affiliations

  1. Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

    Bernhard C. Lechtenberg & David Komander

  2. Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia

    Bernhard C. Lechtenberg & David Komander

Authors
  1. Bernhard C. Lechtenberg
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  2. David Komander
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Correspondence to Bernhard C. Lechtenberg or David Komander.

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Competing interests

D.K. is a co-founder, shareholder, and scientific advisory board member of Entact Bio.

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Lechtenberg, B.C., Komander, D. Just how big is the ubiquitin system?. Nat Struct Mol Biol 31, 210–213 (2024). https://doi.org/10.1038/s41594-023-01208-z

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