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Thinking outside the chromosome: epigenetic mechanisms in non-canonical chromatin species

Nature Structural & Molecular Biology volume 31, pages 8–10 (2024)Cite this article

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Here we investigate the role of epigenetics in the formation, transcription regulation, maintenance and termination of several non-canonical chromatin structures. Using two examples, we demonstrate how studying non-canonical structures may reveal underlying mechanisms with implications for disease and propose intriguing epigenetic avenues for further exploration.

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Authors and Affiliations

  1. Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Albert S. Agustinus

  2. Pharmacology Graduate Program, Weill Cornell Medicine, New York, NY, USA

    Albert S. Agustinus & Yael David

  3. Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Yael David

  4. Tri-institutional PhD Program in Chemical Biology, New York, NY, USA

    Yael David

Authors
  1. Albert S. Agustinus
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  2. Yael David
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Correspondence to Yael David.

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The authors declare no competing financial and/or non-financial interests in relation to the work described.

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Agustinus, A.S., David, Y. Thinking outside the chromosome: epigenetic mechanisms in non-canonical chromatin species. Nat Struct Mol Biol 31, 8–10 (2024). https://doi.org/10.1038/s41594-023-01200-7

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