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Ferroptosis

FSP1 inhibition: pick your pocket

Nature Structural & Molecular Biology volume 30, pages 1618–1619 (2023)Cite this article

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Ferroptosis suppressor protein 1 (FSP1, or AIFM2), an NADPH quinone reductase noted to protect cancer cells from ferroptosis, acts in FAD/NADPH binding and proton transfer. Recent papers assess its evolutionarily conserved sites via mutagenesis and define its inhibition as an off-target mediator of brequinar-mediated ferroptosis sensitization.

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Fig. 1: Schematic of FSP1 inhibitor modes-of-action.

References

  1. Dixon, S. J. et al. Cell 149, 1060–1072 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Viswanathan, V. S. et al. Nature 547, 453–457 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hangauer, M. J. et al. Nature 551, 247–250 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Doll, S. et al. Nature 149, 1060–20 (2019).

    Google Scholar 

  5. Bersuker, K. et al. Nature 575, 688–692 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Mishima, E. et al. Nature 608, 778–783 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Zhang, S. et al. Cell Res. https://doi.org/10.1038/s41422-023-00879-z (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Müller, F. et al. Cell Death Differ. 30, 442–456 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Koppula, P. et al. Nat. Commun. 13, 2206 (2022).

    Article  CAS  PubMed Central  Google Scholar 

  10. Nakamura, T. et al. Nature 619, 371–377 (2023).

    Article  CAS  PubMed Central  Google Scholar 

  11. Nakamura, T. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01136-y (2023).

    Article  Google Scholar 

  12. Mishima, E. et al. Nature 619, E9–E18 (2023).

    Article  CAS  PubMed  Google Scholar 

  13. Mao, C. et al. Nature 593, 586–590 (2021). Cell Death Dis. 14, 1–9 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Xavier da Silva, T. N., Schulte, C., Alves, A. N., Maric, H. M. & Friedmann Angeli, J. P. Cell Death Dis 14, 1–9 (2023).

  15. Hendricks, J. M. et al. Cell Chem. Biol. 30, 1090–1103.e7 (2023).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

S.v.K. receives funding from collaborative research center grants (SFB1403, ID 414786233; SFB1530, ID 455784452; SFB1399, ID 413326622 and SFB1310, ID 325931972), through a priority program on ferroptosis (SPP2306, ID 461704389) all funded by the German Research Foundation (Deutsche Forschungsgesellschaft, DFG), and via CANTAR, which is funded through the program Netzwerke 2021, an initiative of the Ministry of Culture and Science of the State of Northrhine Westphalia, Germany.

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Authors and Affiliations

  1. University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany

    Christina M. Bebber & Silvia von Karstedt

  2. CECAD Cluster of Excellence, University of Cologne, Cologne, Germany

    Christina M. Bebber & Silvia von Karstedt

  3. University of Cologne, Faculty of Medicine and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany

    Silvia von Karstedt

Authors
  1. Christina M. Bebber
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  2. Silvia von Karstedt
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Correspondence to Silvia von Karstedt.

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The authors declare no competing interests.

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Bebber, C.M., von Karstedt, S. FSP1 inhibition: pick your pocket. Nat Struct Mol Biol 30, 1618–1619 (2023). https://doi.org/10.1038/s41594-023-01145-x

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