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Phospholipid synthesis

Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1

Nature Structural & Molecular Biology volume 30, pages 1247–1250 (2023)Cite this article

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New cryo-electron microscopy (cryo-EM) structures of CDP- and CDP-choline-bound choline phosphotransferase 1 (CHPT1) and choline/ethanolamine phosphotransferase 1 (CEPT1), involved in the metabolism of the two main lipids in eukaryotic cell membranes, capture the membrane proteins at resolution <4 Å, sufficient to gain mechanistic insights into these enzymes.

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Fig. 1: CHPT and CEPT in the context of lipid biosynthesis, the reaction catalyzed by them and their internal symmetry.
Fig. 2: Structural basis of substrate interactions and catalysis by CEPTs.

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  1. Section on Structural and Chemical Biology, Neurosciences and Cellular and Structural Biology Division, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA

    Rahul Raina & Anirban Banerjee

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  1. Rahul Raina
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  2. Anirban Banerjee
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Correspondence to Anirban Banerjee.

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Raina, R., Banerjee, A. Architects of the membrane: structures of eukaryotic choline phosphotransferase 1 and choline/ethanolamine phosphotransferase 1. Nat Struct Mol Biol 30, 1247–1250 (2023). https://doi.org/10.1038/s41594-023-01073-w

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