Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Chromatin modification

The NuA4 histone acetyltransferase: variations on a theme of SAGA

Nature Structural & Molecular Biology volume 30, pages 1240–1241 (2023)Cite this article

Subjects

NuA4 is a highly conserved histone acetyltransferase complex that functions in transcription and DNA repair. Four groups have recently determined the structure of NuA4 from two different yeasts using cryo-EM, revealing important mechanistic details of its function and allowing a detailed comparison to the related SAGA complex.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Comparison of Tra1 integration by the NuA4 and SAGA complexes, highlighting the overlapping interface made with the Tra1 FAT domain.

References

  1. Brown, C. E. et al. Science 292, 2333–2337 (2001).

    Article  CAS  PubMed  Google Scholar 

  2. Morgan, M. A. J. & Shilatifard, A. Nat. Genet. 52, 1271–1281 (2020).

    Article  CAS  PubMed  Google Scholar 

  3. Fréchard, A. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-023-01056-x (2023).

    Article  PubMed  Google Scholar 

  4. Qu, K., Chen, K., Wang, H., Li, X. & Chen, Z. Nature 610, 569–574 (2022).

    Article  CAS  PubMed  Google Scholar 

  5. Zukin, S. A. et al. Elife 11, e81400 (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Ji, L. et al. Proc. Natl Acad. Sci. USA 119, e2214313119 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Wang, X., Ahmad, S., Zhang, Z., Côté, J. & Cai, G. Nat. Commun. 9, 1147 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Wang, H. et al. Nature 577, 717–720 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Papai, G. et al. Nature 577, 711–716 (2020).

    Article  CAS  PubMed  Google Scholar 

  10. Herbst, D. A. et al. Nat. Struct. Mol. Biol. 28, 989–996 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Díaz-Santín, L. M., Lukoyanova, N., Aciyan, E. & Cheung, A. C. Elife 6, e28384 (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Xu, P. et al. Mol. Cell 63, 965–975 (2016).

    Article  CAS  PubMed  Google Scholar 

  13. Setiaputra, D. et al. Mol. Cell Biol. 38, e00570–17 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Biochemistry, University of Bristol, Bristol, UK

    Alan C. M. Cheung

Authors
  1. Alan C. M. Cheung
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alan C. M. Cheung.

Ethics declarations

Competing interests

The author declares no competing interests

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cheung, A.C.M. The NuA4 histone acetyltransferase: variations on a theme of SAGA. Nat Struct Mol Biol 30, 1240–1241 (2023). https://doi.org/10.1038/s41594-023-01057-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41594-023-01057-w

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing