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Dosage compensation

A fine balancing act: how epitranscriptome regulates dosage compensation in mammals

Nature Structural & Molecular Biology volume 30, pages 1057–1059 (2023)Cite this article

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Unlike autosomal genes, X-linked genes are expressed from only one copy in both male and female mammals. How cells increase X-linked gene expression to match autosomal levels is unclear. New evidence suggests that lower levels of RNA modifications on X chromosome-derived transcripts critically regulate mRNA stability and help to balance X-to-autosome gene expression levels.

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Fig. 1: Levels of m6A regulate mRNA degradation and balance the X-to-A transcripts ratios in mouse and human cells.

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Acknowledgements

The author is funded by the European Union (ERC-STG, DarkCellFader, #1010770480) and Austrian Academy of Science, and thanks M. Borsos and D. Honson for suggestions made to the text.

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  1. Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA), Vienna Biocenter (VBC), Vienna, Austria

    Joanna W. Jachowicz

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  1. Joanna W. Jachowicz
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Correspondence to Joanna W. Jachowicz.

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Jachowicz, J.W. A fine balancing act: how epitranscriptome regulates dosage compensation in mammals. Nat Struct Mol Biol 30, 1057–1059 (2023). https://doi.org/10.1038/s41594-023-01055-y

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