Inactivation of one of the two female X chromosomes involves condensing it into a repressive subnuclear territory, which is depleted of transcriptional components and undergoes late-stage DNA replication. Two new studies unravel how compartmentalization of the inactive mammalian X chromosome affects transcription and DNA replication.
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Zimmer, F., Basilicata, M.F. & Keller Valsecchi, C.I. Transcription and replication meet the silent X chromosome territory. Nat Struct Mol Biol 30, 1054–1056 (2023). https://doi.org/10.1038/s41594-023-01054-z
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DOI: https://doi.org/10.1038/s41594-023-01054-z