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DNA repair

Actin up: shifting chromosomes toward repair, but also translocations

Nature Structural & Molecular Biology volume 30, pages 2–4 (2023)Cite this article

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Nuclear actin polymerization helps facilitate chromosome compartment switches that can shift damaged DNA toward a nuclear environment that is favorable for DNA repair. Yet shifting multiple broken DNA strands together can also increase the likelihood of misjoining of the DNA ends and subsequent formation of translocations.

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Fig. 1: Nuclear actin polymerization facilitates compartment shifts and DNA break clustering.

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Acknowledgements

Work in the McCord laboratory is funded by US National Institutes of Health/National Institute of General Medical Science grant R35GM133557 to R.P.M.

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  1. Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, TN, USA

    Heng Li & Rachel Patton McCord

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  1. Heng Li
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  2. Rachel Patton McCord
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Correspondence to Rachel Patton McCord.

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The authors declare no competing interests.

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Li, H., McCord, R.P. Actin up: shifting chromosomes toward repair, but also translocations. Nat Struct Mol Biol 30, 2–4 (2023). https://doi.org/10.1038/s41594-022-00906-4

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