New work on DNA polymerase λ highlights its remarkable flexibility. This fits with the generally adaptable nature of the DNA-repair process in which this enzyme is involved—nonhomologous end-joining—which allows this mechanism to handle diverse types of broken DNA ends in order to restore the duplex structure, albeit with a loss of information at the join.
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Zhao, B., Rothenberg, E., Ramsden, D. A. & Lieber, M. R. Nat. Rev. Mol. Cell Biol. 21, 765–781 (2020).
Moore, J. K. & Haber, J. E. Mol. Cell. Biol. 16, 2164–2173 (1996).
Han, L. & Yu, K. J. Exp. Med. 205, 2745–2753 (2008).
Chiruvella, K. K., Liang, Z., Birkeland, S. R., Basrur, V. & Wilson, T. E. PLoS Genet. 9, e1003599 (2013).
Cottarel, J. et al. J. Cell Biol. 200, 173–186 (2013).
Goff, N. J. et al. Nucleic Acids Res. 50, 11058–11071 (2022).
Zhao, B. et al. Nat. Commun. 10, 3588 (2019).
Chandramouly, G. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-022-00895-4 (2022).
Kaminski, A. M. et al. Nat. Commun. 13, 3806 (2022).
Zhao, B., Watanabe, G. & Lieber, M. R. Nucleic Acids Res. 48, 3605–3618 (2020).
Lieber, M. R., Ma, Y., Pannicke, U. & Schwarz, K. DNA Repair 3, 817–826 (2004).
Gu, J. & Lieber, M. R. Genes Dev. 22, 411–415 (2008).
Lieber, M. R. J. Biol. Chem. 283, 1–5 (2008).
Ramsden, D. A., Carvajal-Garcia, J. & Gupta, G. P. Nat. Rev. Mol. Cell Biol. 23, 125–140 (2022).
M.R.L. is supported by National Interests of Health grants GM118009 and CA100504.
The author declares no competing interests.
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Lieber, M.R. Pol X DNA polymerases contribute to NHEJ flexibility. Nat Struct Mol Biol 30, 5–8 (2023). https://doi.org/10.1038/s41594-022-00904-6
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