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Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta

MFSD2A mediates uptake of the essential fatty acid DHA across the blood–brain barrier. Separately, via interactions with syncytin-2, MFSD2A contributes to the formation of the mother–fetus placental boundary. Cryo-EM analysis of a human MFSD2A–syncytin-2 complex provides new insights into how MFSD2A performs these dual roles.

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Fig. 1: Multiple barrier functions of MFSD2A in brain and placenta.
Fig. 2: Lipid transport mechanisms are coming into focus.


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Research in the lab of M.A.S. is funded by the European Research Council (ERC; consolidator grant no. 772190) and by a project grant of the Swiss National Science Foundation (310030_188817).

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Correspondence to Justin D. Walter or Markus A. Seeger.

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Walter, J.D., Remm, S. & Seeger, M.A. Fatty acid transporter MFSD2A is a multifunctional gatekeeper in brain and placenta. Nat Struct Mol Biol 29, 504–506 (2022).

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