Transcription of eukaryotic protein-coding genes involves co-activator complexes, including TFIID and SAGA. A new study has determined the first high-resolution cryo-EM structure of the human SAGA complex, and has implications for defining SAGA function during multiple stages of eukaryotic transcription.
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References
Soffers, J. H. M. & Workman, J. L. Genes Dev. 34, 1287–1303 (2020).
Atanassov, B. S. et al. Mol. Cell 35, 352–364 (2009).
Donczew, R., Warfield, L., Pacheco, D., Erijman, A. & Hahn, S. eLife 9, e50109 (2020).
Warfield, L. et al. Mol. Cell 68, 118–129.e5 (2017).
Baptista, T. et al. Mol. Cell 68, 130–143.e5 (2017).
Basehoar, A. D., Zanton, S. J. & Pugh, B. F. Cell 116, 699–709 (2004).
Patel, A. B. et al. Science 362, eaau8872 (2018).
Papai, G. et al. Nature 577, 711–716 (2020).
Chen, X. et al. Science 372, eaba8490 (2021).
Grant, P. A. et al. Genes Dev. 11, 1640–1650 (1997).
Brownell, J. E. et al. Cell 84, 843–851 (1996).
Martinez, E. et al. Mol. Cell. Biol. 21, 6782–6795 (2001).
Brand, M. et al. EMBO J. 20, 3187–3196 (2001).
Wieczorek, E., Brand, M., Jacq, X. & Tora, L. Nature 393, 187–191 (1998).
Sermwittayawong, D. & Tan, S. EMBO J. 25, 3791–3800 (2006).
Louder, R. K. et al. Nature 531, 604–609 (2016).
Nogales, E. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-021-00682-7 (2021).
Daniel, J. A. et al. J. Biol. Chem. 279, 1867–1871 (2004).
Henry, K. W. et al. Genes Dev. 17, 2648–2663 (2003).
Morgan, M. T. et al. Science 351, 725–728 (2016).
Li, X. et al. Genes Dev. 31, 1588–1600 (2017).
Wang, H. et al. Nature 577, 717–720 (2020).
Díaz-Santín, L. M., Lukoyanova, N., Aciyan, E. & Cheung, A. C. eLife 6, e28384 (2017).
Gat, Y. et al. Nat. Struct. Mol. Biol. 26, 1089–1093 (2019).
Scaiola, A. et al. Sci. Adv. 6, eabc1251 (2020).
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Vos, S.M. Chronicles of the human SAGA co-activator complex. Nat Struct Mol Biol 28, 959–960 (2021). https://doi.org/10.1038/s41594-021-00696-1
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DOI: https://doi.org/10.1038/s41594-021-00696-1
