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DNA DAMAGE REPAIR

Is it a wrap? Nucleosome interactions of the BRCA1-binding partner, BARD1, steal the scene

Emerging findings provide compelling evidence that the BRCA1-binding partner BARD1 contributes yet further to BRCA1 function. BARD1 is crucial for positioning the E2 ubiquitin-conjugating enzyme that confers specificity of its ligase to residues on histone H2A, and BARD1 also promotes DNA damage–induced chromatin recruitment through an interaction with ubiquitin-conjugated Lys13 or Lys15 of H2A on the nucleosome core particle.

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Fig. 1: Nucleosome interactions of BARD1.

References

  1. 1.

    Coleman, K. A. & Greenberg, R. A. J. Biol. Chem. 286, 13669–13680 (2011).

    CAS  Article  Google Scholar 

  2. 2.

    Hu, Y. et al. Genes Dev. 25, 685–700 (2011).

    CAS  Article  Google Scholar 

  3. 3.

    Doil, C. et al. Cell 136, 435–446 (2009).

    CAS  Article  Google Scholar 

  4. 4.

    Kim, H., Chen, J. & Yu, X. Science 316, 1202–1205 (2007).

    CAS  Article  Google Scholar 

  5. 5.

    Kalb, R. et al. Cell Rep. 8, 999–1005 (2014).

    CAS  Article  Google Scholar 

  6. 6.

    McGinty, R. K., Henrici, R. C. & Tan, S. Nature 514, 591–596 (2014).

    CAS  Article  Google Scholar 

  7. 7.

    Hu, Q. et al. Nature 596, 438–443 (2021).

    CAS  Article  Google Scholar 

  8. 8.

    Becker, J. R. et al. Nature 596, 33–437 (2021).

    Article  Google Scholar 

  9. 9.

    Witus, S. R. et al. Nat. Struct. Mol. Biol. 28, 268–277 (2021).

    CAS  Article  Google Scholar 

  10. 10.

    Dai, L. et al. Mol. Cell. 81, 2765–2777 (2021).

    CAS  Article  Google Scholar 

  11. 11.

    Krais, J. J. et al. Nat. Commun. 12, 5016 (2021).

    CAS  Article  Google Scholar 

  12. 12.

    Nakamura, K. et al. Nat. Cell Biol. 21, 311–318 (2019).

    CAS  Article  Google Scholar 

  13. 13.

    Wilson, M. D. et al. Nature 536, 100–103 (2016).

    CAS  Article  Google Scholar 

  14. 14.

    Li, M. & Yu, X. Cancer Cell 23, 693–704 (2013).

    CAS  Article  Google Scholar 

  15. 15.

    Wu, W. et al. Cancer Res. 75, 1311–1321 (2015).

    CAS  Article  Google Scholar 

  16. 16.

    Sherker, A. et al. Preprint at bioRxiv https://doi.org/10.1101/2021.07.21.452958 (2021).

  17. 17.

    Zhu, Q. et al. Mol. Cell. 70, 842–853 (2018).

    CAS  Article  Google Scholar 

  18. 18.

    Densham, R. M. et al. Nat. Struct. Mol. Biol. 23, 647–655 (2016).

    CAS  Article  Google Scholar 

  19. 19.

    Uckelmann, M. et al. Nat. Commun. 9, 229 (2018).

    Article  Google Scholar 

  20. 20.

    Reid, L. J. et al. Proc. Natl Acad. Sci. USA 105, 20876–20881 (2008).

    CAS  Article  Google Scholar 

  21. 21.

    Sato, K. et al. Curr. Biol. 22, 1659–1666 (2012).

    CAS  Article  Google Scholar 

  22. 22.

    Stewart, M. D. et al. Proc. Natl Acad. Sci. USA. 115, 1316–1321 (2018).

    CAS  Article  Google Scholar 

  23. 23.

    Wang, Y. et al. J. Clin. Invest. 126, 3145–3157 (2016).

    Article  Google Scholar 

  24. 24.

    Drost, R. et al. J. Clin. Invest. 126, 2903–2918 (2016).

    Article  Google Scholar 

  25. 25.

    Li, M. et al. EMBO Rep. 17, 1532–1541 (2016).

    CAS  Article  Google Scholar 

Download references

Acknowledgements

I thank the University of Birmingham.

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Correspondence to Joanna R. Morris.

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Morris, J.R. Is it a wrap? Nucleosome interactions of the BRCA1-binding partner, BARD1, steal the scene. Nat Struct Mol Biol 28, 708–710 (2021). https://doi.org/10.1038/s41594-021-00658-7

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