Pervasive genome-wide transcription initiation by RNA polymerase II (Pol II) necessitates mechanisms that restrain the quantity and length of the transcripts. A new study investigates a mechanism for inducing early transcription termination, employed primarily at genomic regions producing noncoding RNAs.
Access options
Subscribe to Journal
Get full journal access for 1 year
$59.00
only $4.92 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Rent or Buy article
Get time limited or full article access on ReadCube.
from$8.99
All prices are NET prices.

Change history
02 April 2021
A Correction to this paper has been published: https://doi.org/10.1038/s41594-021-00588-4
References
- 1.
Austenaa, L. M. I. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-021-00572-y (2021).
- 2.
Austenaa, L. M. I. et al. Mol. Cell 60, 460–474 (2015).
- 3.
Brewer-Jensen, P. et al. RNA 22, 139–154 (2016).
- 4.
Cheng, H., He, X. & Moore, C. Mol. Cell. Biol. 24, 2932–2943 (2004).
- 5.
Estell, C., Davidson, L., Steketee, P. C., Monier, A. & West, S. Preprint at bioRxiv https://doi.org/10.1101/2021.02.10.430684 (2021).
- 6.
Hazelbaker, D. Z., Marquardt, S., Wlotzka, W. & Buratowski, S. Mol. Cell 49, 55–66 (2013).
- 7.
Schaukowitch, K. et al. Mol. Cell 56, 29–42 (2014).
- 8.
Mousavi, K. et al. Mol. Cell 51, 606–617 (2013).
- 9.
Hamazaki, N., Uesaka, M., Nakashima, K., Agata, K. & Imamura, T. Development 142, 910–920 (2015).
- 10.
Gil, N. & Ulitsky, I. Cell Syst 7, 537–547.e3 (2018).
- 11.
Tan, J. Y., Biasini, A., Young, R. S. & Marques, A. C. Life Sci. Alliance 3, e202000663 (2020).
- 12.
Tan, J. Y. & Marques, A. C. Preprint at bioRxiv https://doi.org/10.1101/2020.04.17.045971 (2020).
- 13.
Ntini, E., Budach, S., Vang Ørom, U. A. & Marsico, A. Preprint at bioRxiv https://doi.org/10.1101/2020.12.15.422063 (2020).
- 14.
Lykke-Andersen, S. et al. Mol. Cell 81, 514–529.e6 (2021).
- 15.
Rosa-Mercado, N. A. et al. Mol. Cell 81, 502–513.e4 (2021).
- 16.
Vilborg, A., Passarelli, M. C., Yario, T. A., Tycowski, K. T. & Steitz, J. A. Mol. Cell 59, 449–461 (2015).
- 17.
Wu, X. & Sharp, P. A. Cell 155, 990–996 (2013).
Author information
Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Gil, N., Ulitsky, I. Inefficient splicing curbs noncoding RNA transcription. Nat Struct Mol Biol (2021). https://doi.org/10.1038/s41594-021-00582-w
Published: