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Inefficient splicing curbs noncoding RNA transcription

An Author Correction to this article was published on 01 April 2021

This article has been updated

Pervasive genome-wide transcription initiation by RNA polymerase II (Pol II) necessitates mechanisms that restrain the quantity and length of the transcripts. A new study investigates a mechanism for inducing early transcription termination, employed primarily at genomic regions producing noncoding RNAs.

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Fig. 1: The WDR82–ZC3H4 complex curbs noncoding RNA transcription.

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References

  1. 1.

    Austenaa, L. M. I. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-021-00572-y (2021).

  2. 2.

    Austenaa, L. M. I. et al. Mol. Cell 60, 460–474 (2015).

    CAS  Article  Google Scholar 

  3. 3.

    Brewer-Jensen, P. et al. RNA 22, 139–154 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Cheng, H., He, X. & Moore, C. Mol. Cell. Biol. 24, 2932–2943 (2004).

    CAS  Article  Google Scholar 

  5. 5.

    Estell, C., Davidson, L., Steketee, P. C., Monier, A. & West, S. Preprint at bioRxiv https://doi.org/10.1101/2021.02.10.430684 (2021).

  6. 6.

    Hazelbaker, D. Z., Marquardt, S., Wlotzka, W. & Buratowski, S. Mol. Cell 49, 55–66 (2013).

    CAS  Article  Google Scholar 

  7. 7.

    Schaukowitch, K. et al. Mol. Cell 56, 29–42 (2014).

    CAS  Article  Google Scholar 

  8. 8.

    Mousavi, K. et al. Mol. Cell 51, 606–617 (2013).

    CAS  Article  Google Scholar 

  9. 9.

    Hamazaki, N., Uesaka, M., Nakashima, K., Agata, K. & Imamura, T. Development 142, 910–920 (2015).

    CAS  Article  Google Scholar 

  10. 10.

    Gil, N. & Ulitsky, I. Cell Syst 7, 537–547.e3 (2018).

    CAS  Article  Google Scholar 

  11. 11.

    Tan, J. Y., Biasini, A., Young, R. S. & Marques, A. C. Life Sci. Alliance 3, e202000663 (2020).

    Article  Google Scholar 

  12. 12.

    Tan, J. Y. & Marques, A. C. Preprint at bioRxiv https://doi.org/10.1101/2020.04.17.045971 (2020).

  13. 13.

    Ntini, E., Budach, S., Vang Ørom, U. A. & Marsico, A. Preprint at bioRxiv https://doi.org/10.1101/2020.12.15.422063 (2020).

  14. 14.

    Lykke-Andersen, S. et al. Mol. Cell 81, 514–529.e6 (2021).

    CAS  Article  Google Scholar 

  15. 15.

    Rosa-Mercado, N. A. et al. Mol. Cell 81, 502–513.e4 (2021).

    CAS  Article  Google Scholar 

  16. 16.

    Vilborg, A., Passarelli, M. C., Yario, T. A., Tycowski, K. T. & Steitz, J. A. Mol. Cell 59, 449–461 (2015).

    CAS  Article  Google Scholar 

  17. 17.

    Wu, X. & Sharp, P. A. Cell 155, 990–996 (2013).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Noa Gil or Igor Ulitsky.

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Gil, N., Ulitsky, I. Inefficient splicing curbs noncoding RNA transcription. Nat Struct Mol Biol (2021). https://doi.org/10.1038/s41594-021-00582-w

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