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Kicking off sphingolipid biosynthesis: structures of the serine palmitoyltransferase complex

Nature Structural & Molecular Biology volume 28, pages 229–231 (2021)Cite this article

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Structures of the human serine palmitoyltransferase complex reveal the overall assembly, regulatory mechanisms and substrate selectivity of this key enzyme in sphingolipid synthesis.

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Fig. 1: The sphingolipid metabolic pathway.
Fig. 2: Structure of the serine palmitoyltransferase complex.

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Acknowledgements

This work was supported by NIH R01HL131340 to B.W.

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  1. Department of Biochemistry and Molecular Biology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA

    Binks W. Wattenberg

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  1. Binks W. Wattenberg
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Correspondence to Binks W. Wattenberg.

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Wattenberg, B.W. Kicking off sphingolipid biosynthesis: structures of the serine palmitoyltransferase complex. Nat Struct Mol Biol 28, 229–231 (2021). https://doi.org/10.1038/s41594-021-00562-0

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