During translesion synthesis, eukaryotic DNA polymerase ζ carries out extension from a wide range of DNA lesions. Elucidation of the cryo-EM structure of polymerase ζ reveals how the enzyme catalyzes DNA strand synthesis beyond the lesion.
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Washington, M.T., Gildenberg, M.S. Structure of DNA polymerase ζ: capturing the getaway driver. Nat Struct Mol Biol 27, 1–2 (2020). https://doi.org/10.1038/s41594-020-0502-9
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DOI: https://doi.org/10.1038/s41594-020-0502-9
