Visualizing siRNA targeting of single mRNAs in living cells reveals that passing ribosomes temporarily unfold the mRNA, exposing it to siRNA recognition. This effect is due to the slow reorganization of many weak, suboptimal interactions within the mRNA.
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Małecka, E.M., Woodson, S.A. Ribosomes clear the way for siRNA targeting. Nat Struct Mol Biol 27, 775–777 (2020). https://doi.org/10.1038/s41594-020-0495-4
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DOI: https://doi.org/10.1038/s41594-020-0495-4
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