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RNA EDITING

It takes two (and some distance) to tango: how ADARs join to edit RNA

Nature Structural & Molecular Biology volume 27, pages 308–310 (2020)Cite this article

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Adenosine deaminases acting on RNA (ADARs) catalyze deamination of adenosine to inosine. irCLASH identifies dsRNA substrates of ADARs and defines new features of their RNA-binding and editing activity, improving our understanding of these enzymes and aiding with future therapeutic applications.

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Fig. 1: Cellular activity of ADAR proteins.
Fig. 2: Novel features of ADAR editing activity.

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Authors and Affiliations

  1. Division of Immune Diversity (D150), German Cancer Research Center (DKFZ), Heidelberg, Germany

    Riccardo Pecori & Nina F. Papavasiliou

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  1. Riccardo Pecori
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  2. Nina F. Papavasiliou
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Correspondence to Riccardo Pecori or Nina F. Papavasiliou.

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The author declares no competing interests.

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Pecori, R., Papavasiliou, N.F. It takes two (and some distance) to tango: how ADARs join to edit RNA. Nat Struct Mol Biol 27, 308–310 (2020). https://doi.org/10.1038/s41594-020-0411-y

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