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BACTERIAL FLAGELLAR MOTOR

A proposed gear mechanism for torque generation in the flagellar motor

In situ structures of the spirochete flagellar motor by cryo-ET reveal two distinct modes of interactions between the rotor ring and stator units. Together with new cryo-EM structures of the isolated stator units, this work provides insights into the mechanisms of torque generation and directional switch.

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Fig. 1: Flagellar basal body rotation and directional switch.

References

  1. Minamino, T. & Namba, K. J. Mol. Microbiol. Biotechnol. 7, 5–17 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Nakamura, S. & Minamino, T. Biomolecules 9, 279 (2019).

    Article  CAS  PubMed Central  Google Scholar 

  3. Berg, H. C. Annu. Rev. Biochem. 72, 19–54 (2003).

    Article  CAS  PubMed  Google Scholar 

  4. Magariyama, Y. et al. Nature 371, 752 (1994).

    Article  CAS  PubMed  Google Scholar 

  5. Fujii, T. et al. Nat. Commun. 8, 14276 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Minamino, T., Terahara, N., Kojima, S. & Namba, K. Mol. Microbiol. 109, 723–734 (2018).

    Article  CAS  PubMed  Google Scholar 

  7. Thomas, D., Francis, N. R., Xu, C. & DeRosier, D. J. J. Bacteriol. 188, 7039–7048 (2006).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kawamoto, A. et al. Sci. Rep. 3, 3369 (2013).

    Article  PubMed  PubMed Central  Google Scholar 

  9. Chang, Y. et al. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-020-0497-2 (2020)

  10. Deme, J. C. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-020-0788-8 (2020).

  11. Santiveri, M. et al. Cell https://doi.org/10.1016/j.cell.2020.08.016 (2020).

  12. Thomas, D. R., Morgan, D. G. & DeRosier, D. J. Proc. Natl Acad. Sci. USA 96, 10134–10139 (1999).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Sakai, T. et al. Mbio 10, e00079–19 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Keiichi Namba.

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Namba, K. A proposed gear mechanism for torque generation in the flagellar motor. Nat Struct Mol Biol 27, 1004–1006 (2020). https://doi.org/10.1038/s41594-020-00514-0

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  • DOI: https://doi.org/10.1038/s41594-020-00514-0

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