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CELIAC DISEASE

The enemy within the gut: bacterial pathogens in celiac autoimmunity

Nature Structural & Molecular Biology volume 27, pages 5–7 (2020)Cite this article

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Microbially derived peptides that mimic immunogenic gliadin peptides in celiac disease have been identified using a structure- and sequence-guided search. T cell activation assays and crystal structures reveal that a protein from the commensal bacterium Pseudomonas fluorescens can be processed and presented by antigen-presenting cells to potently activate T cells from patients with celiac disease.

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Fig. 1: Pathophysiology of the celiac lesion.
Fig. 2: Novel environmental factors that favor breakdown of oral tolerance to gluten.

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Acknowledgements

We thank Heather Galipeau for artistic assistance with the figures. E.F.V. is funded by CIHR #142773 and holds a Canada Research Chair. D.S. receives project-related funding from the German Research Foundation DFG Schu 646/17-1 (ATI), the Collaborative Research Center on Multiple Sclerosis (DFG SFB TR128), DFG SPP 1656 (Intestinal microbiota), and the Leibniz Foundation (Wheatscan, SAW-2016-DFA-2).

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Authors and Affiliations

  1. Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Ontario, Canada

    Elena F. Verdu

  2. Institute of Translation Immunology, University Medical Center, Mainz, Germany

    Detlef Schuppan

  3. Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

    Detlef Schuppan

Authors
  1. Elena F. Verdu
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  2. Detlef Schuppan
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Correspondence to Elena F. Verdu.

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The authors declare no competing interests.

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Verdu, E.F., Schuppan, D. The enemy within the gut: bacterial pathogens in celiac autoimmunity. Nat Struct Mol Biol 27, 5–7 (2020). https://doi.org/10.1038/s41594-019-0360-5

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