The ‘N-end rule’ correlates the identity of the N-terminal residue of a protein to its in vivo half-life. A study has now shown that an N-terminal glycine can serve as a potent degradation signal, which reveals a novel branch of N terminus–dependent protein degradation.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Targeting N-myristoylation for therapy of B-cell lymphomas
Nature Communications Open Access 22 October 2020
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$189.00 per year
only $15.75 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Dikic, I. Annu. Rev. Biochem. 86, 193–224 (2017).
Varshavsky, A. J. Biol. Chem. 283, 34469–34489 (2008).
Varshavsky, A. Proc. Natl Acad. Sci. USA 116, 358–366 (2019).
Varshavsky, A. Annu. Rev. Biochem. 86, 123–128 (2017).
Eldeeb, M. & Fahlman, R. Protein Pept. Lett. 23, 343–348 (2016).
Eldeeb, M. A., Leitao, L. C. A. & Fahlman, R. P. Biochem. Cell Biol. 96, 289–294 (2018).
Bachmair, A., Finley, D. & Varshavsky, A. Science 234, 179–186 (1986).
Tasaki, T., Sriram, S. M., Park, K. S. & Kwon, Y. T. Annu. Rev. Biochem. 81, 261–289 (2012).
Gibbs, D. J., Bacardit, J., Bachmair, A. & Holdsworth, M. J. Trends Cell Biol. 24, 603–611 (2014).
Dissmeyer, N., Rivas, S. & Graciet, E. New Phytol. 218, 929–935 (2018).
Dougan, D. A. & Varshavsky, A. Nat. Chem. Biol. 14, 415–416 (2018).
Eldeeb, M., Fahlman, R., Esmaili, M. & Ragheb, M. Int. J. Mol. Sci. 19, 3414 (2018).
Masson, N. et al. Science 365, 65–69 (2019).
Timms, R. T. et al. Science 365, eaaw4912 (2019).
Chatr-Aryamontri, A., van der Sloot, A. & Tyers, M. Mol. Cell 70, 568–571 (2018).
Emanuele, M. J. et al. Cell 147, 459–474 (2011).
Tasaki, T. et al. Mol. Cell. Biol. 25, 7120–7136 (2005).
Eldeeb, M. A. & Fahlman, R. P. J. Biol. Chem. 291, 22757–22768 (2016).
An, J. Y. et al. Proc. Natl Acad. Sci. USA 103, 6212–6217 (2006).
Lanyon-Hogg, T., Faronato, M., Serwa, R. A. & Tate, E. W. Trends Biochem. Sci. 42, 566–581 (2017).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Eldeeb, M., Esmaili, M. & Fahlman, R. Degradation of proteins with N-terminal glycine. Nat Struct Mol Biol 26, 761–763 (2019). https://doi.org/10.1038/s41594-019-0291-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41594-019-0291-1
This article is cited by
-
Regulation of Neurodegeneration-associated Protein Fragments by the N-degron Pathways
Neurotoxicity Research (2022)
-
Targeting N-myristoylation for therapy of B-cell lymphomas
Nature Communications (2020)
-
N-degron-mediated degradation and regulation of mitochondrial PINK1 kinase
Current Genetics (2020)