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RNA MODIFICATION

Getting a hold on cytosine methylation in mRNA

Cytosine methylation (m5C) is one of the more disputed base modifications of the epitranscriptome, mostly because current methods for detection are prone to artifacts. A new approach to increase detection accuracy reveals intriguing evidence of a role for the tRNA methyltransferase NSUN2 in the methylation of mRNA.

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  • 14 May 2019

    In the version of this article initially published, the author order (Liu, J., Huang, T., Chen, W., Gu, N. & Zhang, R.) for the linked Resource (ref. 7) was incorrect, and all named citations of that reference in the text (“Liu et al.”) were incorrect. The correct author order is “Huang, T., Chen, W., Liu, J., Gu, N. & Zhang, R.” and all named citations should reflect that (“Huang et al.”). The error has been corrected in the HTML and PDF versions of the article.

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Acknowledgements

Research in the author’s laboratory is funded by Austrian Science Fund (FWF) grant P27024-BBL to A.L.

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Correspondence to Alexandra Lusser.

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The authors declare no competing interests.

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Fig. 1: Sequence context of m5C sites in mammalian mRNA.