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ERα condensates: chronic stimulation is hard to ignore

Last year, several studies reported that proteins form biomolecular condensates at gene enhancers. Nair et al. now show that these condensates undergo physical changes over time, which affects their nuclear localization and the transcriptional output of their target genes.

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Fig. 1: Model depicting how enhancer condensates are formed and how they lead to the activation of transcription.

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Correspondence to Simon Alberti.

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S.A. is a scientific advisor of Dewpoint Therapeutics.

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Wittmann, S., Alberti, S. ERα condensates: chronic stimulation is hard to ignore. Nat Struct Mol Biol 26, 153–154 (2019). https://doi.org/10.1038/s41594-019-0198-x

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