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AUTOPHAGY

Crisis management by autophagy

Autophagy is a highly contextual modulator of tumorigenesis. A new study shows that autophagy can serve as a tumor suppressor to mediate cell death at replicative crisis.

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References

  1. 1.

    White, E., Mehnert, J. M. & Chan, C. S. Clin. Cancer Res. 21, 5037–5046 (2015).

  2. 2.

    Nassour, J. et al. Nature https://www.nature.com/articles/s41586-019-0885-0 (2019).

  3. 3.

    Wright, W. E. & Shay, J. W. Exp. Gerontol. 27, 383–389 (1992).

  4. 4.

    Cesare, A. J. & Karlseder, J. Curr. Opin. Cell Biol. 24, 731–738 (2012).

  5. 5.

    Fumagalli, M. et al. Nat. Cell Biol. 14, 355–365 (2012).

  6. 6.

    Hewitt, G. et al. Nat. Commun. 3, 708 (2012).

  7. 7.

    Maciejowski, J. & de Lange, T. Nat. Rev. Mol. Cell Biol. 18, 175–186 (2017).

  8. 8.

    Hanahan, D. & Weinberg, R. A. Cell 144, 646–674 (2011).

  9. 9.

    Li, T. & Chen, Z. J. J. Exp. Med. 215, 1287–1299 (2018).

  10. 10.

    Watson, R. O., Manzanillo, P. S. & Cox, J. S. Cell 150, 803–815 (2012).

  11. 11.

    Liang, Q. et al. Cell Host Microbe 15, 228–238 (2014).

  12. 12.

    Ivanov, A. et al. J. Cell Biol. 202, 129–143 (2013).

  13. 13.

    Dou, Z. et al. Nature 527, 105–109 (2015).

  14. 14.

    Doherty, J. & Baehrecke, E. H. Nat. Cell Biol. 20, 1110–1117 (2018).

  15. 15.

    Cuervo, A. M. Trends Genet. 24, 604–612 (2008).

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Correspondence to Masashi Narita.

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Fig. 1: Two-stage immortalization and autophagy.