Review Article | Published:

Nucleosome structure and dynamics are coming of age

Nature Structural & Molecular Biologyvolume 26pages313 (2019) | Download Citation

Abstract

Since the first high-resolution structure of the nucleosome was reported in 1997, the available information on chromatin structure has increased very rapidly. Here, we review insights derived from cutting-edge biophysical and structural approaches applied to the study of nucleosome dynamics and nucleosome-binding factors, with a focus on the experimental advances driving the research. In addition, we highlight emerging challenges in nucleosome structural biology.

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Acknowledgements

We thank our colleagues J. W. Markert and U. M. Muthurajan for critical reading of this Review. Research in the laboratory of K.L. is supported by the Howard Hughes Medical Institute and by the NIH (CA218255).

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  1. These authors contributed equally: Keda Zhou, Guillaume Gaullier.

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  1. Department of Biochemistry, University of Colorado Boulder, Boulder, CO, USA

    • Keda Zhou
    • , Guillaume Gaullier
    •  & Karolin Luger
  2. Howard Hughes Medical Institute, University of Colorado Boulder, Boulder, CO, USA

    • Guillaume Gaullier
    •  & Karolin Luger

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The authors declare no competing interests.

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Correspondence to Karolin Luger.

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https://doi.org/10.1038/s41594-018-0166-x