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Organellar TRP channels

Nature Structural & Molecular Biology volume 25, pages 1009–1018 (2018)Cite this article

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Abstract

Mammalian transient receptor potential (TRP) channels mediate Ca2+ flux and voltage changes across membranes in response to environmental and cellular signals. At the plasma membrane, sensory TRPs act as neuronal detectors of physical and chemical environmental signals, and receptor-operated (metabotropic) TRPs decode extracellular neuroendocrine cues to control body homeostasis. In intracellular membranes, such as those in lysosomes, organellar TRPs respond to compartment-derived signals to control membrane trafficking, signal transduction, and organelle function. Complementing mouse and human genetics and high-resolution structural approaches, physiological studies employing natural agonists and synthetic inhibitors have become critical in resolving the in vivo functions of metabotropic, sensory, and organellar TRPs.

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Fig. 1: Architecture and functional elements of a TRP channel.
Fig. 2: Metabotropic and sensory TRPs.
Fig. 3: Organellar TRP channels.

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Acknowledgements

We apologize to researchers whose works are not cited owing to space limitations. Research programs in the authors’ laboratory are supported by National Institutes of Health (NIH) grants (NS062792, AR060837, and DK115474). We thank L. Yue, D. Clapham, Y. Jiang, and R. Hume for reading the manuscript and appreciate the encouragement and helpful comments provided by other members of the Xu laboratory.

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  1. These authors contributed equally: Xiaoli Zhang, Meiqin Hu.

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  1. Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA

    Xiaoli Zhang, Meiqin Hu, Yexin Yang & Haoxing Xu

  2. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China

    Meiqin Hu

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Zhang, X., Hu, M., Yang, Y. et al. Organellar TRP channels. Nat Struct Mol Biol 25, 1009–1018 (2018). https://doi.org/10.1038/s41594-018-0148-z

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