We established a method to generate complex self-organizing bone marrow-like organoids (BMOs) via concomitant differentiation of human induced pluripotent stem cells. These BMOs consist of hematopoietic cells, stromal niche cells and de novo vascular networks. In addition, they contain multipotent hematopoietic stem and progenitor cells, as well as mesenchymal stem and progenitor cells; they model aspects of the three-dimensional bone marrow architecture and can be used to study developmental and aberrant hematopoiesis.
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References
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This is a summary of: Frenz-Wiessner, S. et al. Generation of complex bone marrow organoids from human induced pluripotent stem cells. Nat. Methods https://doi.org/10.1038/s41592-024-02172-2 (2024).
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Using stem cells to model the human bone marrow in a dish. Nat Methods (2024). https://doi.org/10.1038/s41592-024-02173-1
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DOI: https://doi.org/10.1038/s41592-024-02173-1
