Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stem cell biology

Modeling the complexity of mammary gland in vitro

A new method models mammary gland in vitro during physiological and pathological conditions.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Cellular composition and structural complexity of mammary gland in vivo and in vitro.

References

  1. Brassard, J. A. & Lutolf, M. P. Cell Stem Cell 24, 860–876 (2019).

    Article  CAS  PubMed  Google Scholar 

  2. Watson, C. J. & Khaled, W. T. Development 147, dev169862 (2020).

    Article  CAS  PubMed  Google Scholar 

  3. Jamieson, P. R. et al. Development 144, 1065–1071 (2017).

    CAS  PubMed  Google Scholar 

  4. Zhang, L. et al. Cell. Signal. 29, 41–51 (2017).

    Article  PubMed  Google Scholar 

  5. Yuan, L. X. et al. Nat. Methods https://doi.org/10.1038/s41592-023-02039-y (2023).

    Article  PubMed  Google Scholar 

  6. Zhang, X. et al. Development 141, 3352–3362 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Wiseman, B. S. & Werb, Z. Science 296, 1046–1049 (2002).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Wuidart, A. et al. Nat. Cell Biol. 20, 666–676 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lilja, A. M. et al. Nat. Cell Biol. 20, 677–687 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Van Keymeulen, A. et al. Nature 479, 189–193 (2011).

    Article  PubMed  Google Scholar 

  11. Van Keymeulen, A. et al. Nature 525, 119–123 (2015).

    Article  PubMed  Google Scholar 

  12. Centonze, A. et al. Nature 584, 608–613 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

C.B. is supported by the WEL Research Institute, FNRS, TELEVIE, EOS FNRS/FWO and the European Research Council.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Cédric Blanpain.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fioramonti, M., Blanpain, C. Modeling the complexity of mammary gland in vitro. Nat Methods 20, 1879–1880 (2023). https://doi.org/10.1038/s41592-023-02064-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41592-023-02064-x

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer