Genome architecture mapping (GAM) enables understanding of 3D genome structure in the nucleus. We directly compared multiplex-GAM and Hi-C data and found that local chromatin interactions were generally detected by both methods, but active genomic regions rich in enhancers that established higher-order contacts were preferentially detected by GAM.
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This is a summary of: Beagrie, R. A. et al. Multiplex-GAM: genome-wide identification of chromatin contacts yields insights overlooked by Hi-C. Nat. Methods https://doi.org/10.1038/s41592-023-01903-1 (2023).
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Genome architecture mapping detects transcriptionally active, multiway chromatin contacts. Nat Methods 20, 993–994 (2023). https://doi.org/10.1038/s41592-023-01905-z
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DOI: https://doi.org/10.1038/s41592-023-01905-z
