Cell type-specific inference of differential expression (C-SIDE) is a statistical model that identifies which genes (within a determined cell type) are differentially expressed on the basis of spatial position, pathological changes or cell–cell interactions. C-SIDE facilitates differential expression analysis in spatial transcriptomics by jointly modeling cell type mixtures and spatially varying gene expression.
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This is a summary of: Cable, D. M. et al. Cell type-specific inference of differential expression in spatial transcriptomics. Nat. Methods https://doi.org/10.1038/s41592-022-01575-3 (2022).
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A statistical method to uncover gene expression changes in spatial transcriptomics. Nat Methods 19, 1046–1047 (2022). https://doi.org/10.1038/s41592-022-01576-2