Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

LAB-ON-A-CHIP

Modeling multi-organ systems on a chip

Nature Methods volume 19, page 641 (2022)Cite this article

Subjects

To recapitulate some of the complexities of the human physiology, engineered tissues can be linked by vascular flow in a multi-organ chip.

Organ-on-a-chip systems can model the biology of individual organs, but the human body exhibits a complex interplay between various organs. Modeling this complexity requires culturing different engineered tissues on a single chip while enabling fluid exchange between the tissues. However, this fluid exchange poses a problem as different tissues require different growth media to achieve and maintain maturity.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

Research paper

  • Ronaldson-Bouchard, K. et al. A multi-organ chip with matured tissue niches linked by vascular flow. Nat. Biomed. Eng. 6, 351–371 (2022).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nature Methods http://www.nature.com/nmeth

    Nina Vogt

Authors
  1. Nina Vogt
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nina Vogt.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Vogt, N. Modeling multi-organ systems on a chip. Nat Methods 19, 641 (2022). https://doi.org/10.1038/s41592-022-01533-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41592-022-01533-z

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing