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Benchmarking experiments with polymer modeling

A study applies polymer physics to assess the advantages and limitations of three sequencing-based approaches for determining the structure of genomes and genomic domains.

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Fig. 1: Computational modeling bypasses the difficulties for benchmarking and assessing the performances of Hi-C, SPRITE and GAM for determining the structure of genomes and genomic domains.


  1. 1.

    Fiorillo, L. et al. Nat. Methods (2021).

    Article  Google Scholar 

  2. 2.

    Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).

    CAS  Article  Google Scholar 

  3. 3.

    Quinodoz, S. A. et al. Cell 174, 744–757.e724 (2018).

    CAS  Article  Google Scholar 

  4. 4.

    Beagrie, R. A. et al. Nature 543, 519–524 (2017).

    CAS  Article  Google Scholar 

  5. 5.

    Misteli, T. Cell 183, 28–45 (2020).

    CAS  Article  Google Scholar 

  6. 6.

    Dekker, J., Rippe, K., Dekker, M. & Kleckner, N. Science 295, 1306–1311 (2002).

    CAS  Article  Google Scholar 

  7. 7.

    Dekker, J., Marti-Renom, M. A. & Mirny, L. A. Nat. Rev. Genet. 14, 390–403 (2013).

    CAS  Article  Google Scholar 

  8. 8.

    Di Stefano, M., Paulsen, J., Jost, D. & Marti-Renom, M. A. Curr. Opin. Genet. Dev. 67, 25–32 (2020).

    Article  Google Scholar 

  9. 9.

    Barbieri, M. et al. Proc. Natl Acad. Sci. USA 109, 16173–16178 (2012).

    CAS  Article  Google Scholar 

  10. 10.

    Bintu, B. et al. Science (2018).

    Article  PubMed  PubMed Central  Google Scholar 

Download references

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Correspondence to Marc A. Marti-Renom.

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Marti-Renom, M.A. Benchmarking experiments with polymer modeling. Nat Methods 18, 456–457 (2021).

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