As single-cell omics continue to advance, the field of spatially resolved transcriptomics has emerged with a set of experimental and computational methods to map out the positions of cells and their gene expression profiles in space. Here we summarize current transcriptome-wide and sequencing-based methodologies and their applications in genomics research.
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L.L. and J.L. wrote the manuscript with input from J.F.
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J.L., J.F. and L.L. are scientific consultants to 10x Genomics Inc.
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Larsson, L., Frisén, J. & Lundeberg, J. Spatially resolved transcriptomics adds a new dimension to genomics. Nat Methods 18, 15–18 (2021). https://doi.org/10.1038/s41592-020-01038-7
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