Reliably identifying ubiquitin ligase interactors and substrates has been a persistent challenge in cellular biology. A breakthrough comes in the form of a potent, selective and cell-active chemical probe, shedding light on the intricate functions of a key regulatory enzyme.
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Xie, S., Li, G. A key to unlock ubiquitin ligase function. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01591-8
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DOI: https://doi.org/10.1038/s41589-024-01591-8