Labeling of endogenous proteins with chemical probes is highly desirable for life science studies. The combination of RNA base editing and site-specific incorporation of non-canonical amino acids allows the introduction of small chemical tags into endogenous proteins in living cells.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Hao, M. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01533-w (2024).
Davis, L. & Chin, J. W. Nat. Rev. Mol. Cell Biol. 13, 168–182 (2012).
Wang, L., Xie, J. & Schultz, P. G. Annu. Rev. Biophys. Biomol. Struct. 35, 225–249 (2006).
Cox, D. B. T. et al. Science 358, 1019–1027 (2017).
Abudayyeh, O. O. et al. Science 365, 382–386 (2019).
Wang, J. et al. Nature 604, 343–348 (2022).
Kramarski, L. & Arbely, E. Nucleic Acids Res. 48, 3747–3760 (2020).
Herring, B. E. & Nicoll, R. A. Annu. Rev. Physiol. 78, 351–365 (2016).
Brown, W., Liu, J. & Deiters, A. ACS Chem. Biol. 13, 2375–2386 (2018).
Wang, D., Tai, P. W. L. & Gao, G. Nat. Rev. Drug Discov. 18, 358–378 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Doura, T., Matsuoka, Y. & Kiyonaka, S. Hijacking endogenous mRNA for genetic code expansion. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01574-9
Published:
DOI: https://doi.org/10.1038/s41589-024-01574-9
