Defining subcellular locations and interacting partners for proteins accelerates their functional characterization. A new in vivo tagging approach achieves both for mitochondrial matrix proteins and helps connect a key oxidoreductase to coenzyme Q biosynthesis.
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Guerra, R.M., Pagliarini, D.J. Reducing mitochondrial mysteries. Nat Chem Biol 20, 132–133 (2024). https://doi.org/10.1038/s41589-023-01435-x
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DOI: https://doi.org/10.1038/s41589-023-01435-x