Cryo-EM structures of chemical-compound-bound α-synuclein amyloid fibrils shed light on the mechanism by which small molecules bind to cross-beta-sheet amyloid structures, opening the gateway to rational drug design for targeting pathological amyloid assemblies.
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Garcia-Pardo, J., Ventura, S. Chemical targeting of amyloids. Nat Chem Biol 19, 1176–1177 (2023). https://doi.org/10.1038/s41589-023-01394-3
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DOI: https://doi.org/10.1038/s41589-023-01394-3
