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Reconsidering the role of protein glycation in disease

Nature Chemical Biology volume 19, pages 922–927 (2023)Cite this article

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Protein glycation has long-been considered a toxic consequence of carbohydrate metabolism. Yet recent evidence demonstrates tight regulation for these non-enzymatic post-translational modifications, pointing to a broader role in cell biology rather than simply serving as a biomarker for toxicity.

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Fig. 1: Metabolic sources of protein glycation.
Fig. 2: Methylglyoxal metabolism.
Fig. 3: Towards relevant study designs in protein glycation.

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Acknowledgements

This work was supported by National Institutes of Health grants (T32 GM008804, for M.N.T. and R35 GM137910, R01 DK133196 for J.J.G.).

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  1. Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, USA

    Marissa N. Trujillo & James J. Galligan

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  1. Marissa N. Trujillo
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Correspondence to James J. Galligan.

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Nature Chemical Biology thanks Yael David, Mogens Johannsen and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Trujillo, M.N., Galligan, J.J. Reconsidering the role of protein glycation in disease. Nat Chem Biol 19, 922–927 (2023). https://doi.org/10.1038/s41589-023-01382-7

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