We identified a comprehensive targetome for glycolytic metabolites in cancer cells using a novel target discovery approach — target responsive accessibility profiling (TRAP). The targetome revealed diverse regulatory modalities for glycolytic metabolites that include engaging with metabolic enzymes, influencing transcriptional outputs and modulating post-translational modification levels, thereby elucidating how glycolytic metabolites function as signaling molecules.
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This is a summary of: Tian, Y. et al. Chemoproteomic mapping of the glycolytic targetome in cancer cells. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01355-w (2023).
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Mapping a comprehensive targetome of glycolytic metabolites in cancer cells. Nat Chem Biol 19, 1446–1447 (2023). https://doi.org/10.1038/s41589-023-01366-7
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DOI: https://doi.org/10.1038/s41589-023-01366-7
