New biochemical and structural studies into the capsule biosynthesis pathway of Haemophilus influenzae serotype b (Hib) provide invaluable insights into a unique, basket-shaped multi-modular enzymatic machinery, allowing accelerated development of fermentation-free production methods for Hib glycoconjugate vaccine.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zarei, A. E., Almehdar, H. A. & Redwan, E. M. J. Immunol. Res. 2016, 7203587 (2016).
Ojo, L. R. et al. Vaccine 28, 7117–7122 (2010).
Verez-Bencomo, V. et al. Science 305, 522–525 (2004).
Satola, S. W., Schirmer, P. L. & Farley, M. M. Infect. Immun. 71, 3639–3644 (2003).
Van Eldere, J. et al. Mol. Microbiol. 15, 107–118 (1995).
Cifuente, J. O. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01324-3 (2023).
Kelly, S. D. et al. Nat. Chem. Biol. 18, 530–537 (2022).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interest.
Rights and permissions
About this article
Cite this article
Dorfmueller, H.C. Basket of sweets. Nat Chem Biol 19, 795–796 (2023). https://doi.org/10.1038/s41589-023-01351-0
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41589-023-01351-0
