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Pharmacology

Metabolic regulation of epigenetic drug resistance

Nature Chemical Biology volume 19, pages 1174–1175 (2023)Cite this article

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A drug-resistance mechanism emphasizes the dependence of epigenetic signaling on acetyl-CoA.

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Fig. 1: Cancer cells tip the balance of acetyl-CoA to overcome HAT inhibition.

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Authors and Affiliations

  1. Department of Cardiovascular Sciences, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA

    Nathaniel W. Snyder

  2. Chemical Biology Laboratory, National Cancer Institute, Frederick, MD, USA

    Jordan L. Meier

Authors
  1. Nathaniel W. Snyder
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  2. Jordan L. Meier
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Correspondence to Nathaniel W. Snyder or Jordan L. Meier.

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Snyder, N.W., Meier, J.L. Metabolic regulation of epigenetic drug resistance. Nat Chem Biol 19, 1174–1175 (2023). https://doi.org/10.1038/s41589-023-01323-4

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