Identifying new proteoforms — structural variants of proteins — is frequently challenging, particularly on the proteome-wide scale. A new study leverages their differential thermal stabilities to identify proteoform functional groups by deep thermal proteome profiling.
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The authors declare no competing interests.
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Campbell, T.L., Drown, B.S. Proteoforms feel the heat. Nat Chem Biol (2023). https://doi.org/10.1038/s41589-023-01285-7