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Protein design

Peptides hit the catalysis walk

Nature Chemical Biology volume 19, pages 395–396 (2023)Cite this article

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A protein–protein interface between a peptide-recognition domain (Fyn-SH3) and catechol O-methyltransferase (COMT) is computationally designed to generate a highly selective peptide-modifying system. Detailed mechanistic analysis sets a gold standard for studying the complex kinetic properties of designer fusion proteins.

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Fig. 1: Computational design of a protein–protein interface between a peptide-recognition domain (Fyn-SH3) and catechol O-methyltransferase (COMT).

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Authors and Affiliations

  1. Department of Chemistry, University of Wisconsin–Madison, Madison, WI, USA

    Jonathan M. Ellis & Andrew R. Buller

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  1. Jonathan M. Ellis
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  2. Andrew R. Buller
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Correspondence to Andrew R. Buller.

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The authors declare no competing interests.

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Ellis, J.M., Buller, A.R. Peptides hit the catalysis walk. Nat Chem Biol 19, 395–396 (2023). https://doi.org/10.1038/s41589-022-01210-4

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