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Microbiology

The τ of alarmone hydrolysis

Bacteria utilize stringent factors to metabolize the nucleotide alarmone guanosine tetra-/pentaphosphate, or (p)ppGpp, for stress adaptation. Now, a distinct conformation of these factors explaining their regulation and specialization has been unveiled.

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Correspondence to Jue D. Wang.

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Fung, D.K., Wang, J.D. The τ of alarmone hydrolysis. Nat Chem Biol 19, 257–258 (2023). https://doi.org/10.1038/s41589-022-01200-6

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