In the post-genomic era, many genes and regulatory elements remain uncharacterized, including riboswitches — RNA structures that control gene expression by directly binding metabolites. Here, a new type of metal-responsive riboswitch that senses sodium cations expands the bacterial Na+ metabolic repertoire.
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References
Serganov, A. & Nudler, E. Cell 152, 17–24 (2013).
Breaker, R. R. Biochemistry 61, 137–149 (2022).
Saunders, A. M. & DeRose, V. J. Curr. Opin. Chem. Biol. 31, 153–159 (2016).
White, N., Sadeeshkumar, H., Sun, A., Sudarsan, N. & Breaker, R. R. Nat. Chem. Biol. https://doi.org/10.1038/s41589-022-01086-4 (2022).
Sherlock, M. E. & Breaker, R. R. RNA 26, 675–693 (2020).
Ireland, W. T. et al. Elife 9, 55308 (2020).
Ghatak, S., King, Z. A., Sastry, A. & Palsson, B. O. Nucleic Acids Res. 47, 2446–2454 (2019).
Ferré-D’Amaré, A. R. & Winkler, W. C. Met. Ions Life Sci. 9, 141–173 (2011).
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Waters, L. A new class of metal-sensing RNA. Nat Chem Biol 18, 798–799 (2022). https://doi.org/10.1038/s41589-022-01087-3
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DOI: https://doi.org/10.1038/s41589-022-01087-3
