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Putting a leash on Hippo

Nature Chemical Biology volume 18, pages 1039–1040 (2022)Cite this article

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The Hippo pathway is a key regulator of tissue homeostasis, organ size and cancer. Identification of microcolin B and its analog molecules as Hippo pathway activators connects PtdIns4P-dependent lipid signaling with the Hippo pathway, suggesting potential targets for cancer therapy.

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Fig. 1: Phospholipids are key regulators of the Hippo pathway.

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  1. Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA

    Gayoung Seo & Wenqi Wang

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  1. Gayoung Seo
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  2. Wenqi Wang
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Correspondence to Wenqi Wang.

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The authors declare no competing interests.

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Seo, G., Wang, W. Putting a leash on Hippo. Nat Chem Biol 18, 1039–1040 (2022). https://doi.org/10.1038/s41589-022-01066-8

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