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SYNTHETIC BIOLOGY

Enzyme assemblies on demand

Natural enzyme complexes can rapidly change configurations to respond to intracellular cues. Now CRISPR enzymes and programmable RNA scaffolds allow synthetic enzyme complexes to be assembled and disassembled on demand.

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Fig. 1: Dynamic metabolons enable on-demand assembly and disassembly of enzyme complexes.

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Correspondence to Alexander A. Green.

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A.A.G. is a cofounder of En Carta Diagnostics.

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Green, A.A. Enzyme assemblies on demand. Nat Chem Biol 18, 436–438 (2022). https://doi.org/10.1038/s41589-022-01021-7

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