Graspetides are an important class of ribosomal natural products with potent bioactivities. New structural information provides insights into substrate recognition and catalysis, including a rare glimpse into the interactions between a tailoring enzyme and the core of the precursor peptide.
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References
Newman, D. J. & Cragg, G. M. J. Nat. Prod. 83, 770–803 (2020).
Montalbán-López, M. et al. Nat. Prod. Rep. 38, 130–239 (2021).
Arnison, P. G. et al. Nat. Prod. Rep. 30, 108–160 (2013).
Koehnke, J. et al. Nat. Chem. Biol. 11, 558–563 (2015).
Ortega, M. A. et al. Nature 517, 509–512 (2015).
Bothwell, I. R. et al. Proc. Natl. Acad. Sci. USA 116, 17245–17250 (2019).
Song, H. et al. Sci. Adv. 4, eaat2720 (2018).
Grove, T. L. et al. J. Am. Chem. Soc. 139, 11734–11744 (2017).
Song, I. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-021-00855-x (2021).
Li, K., Condurso, H. L., Li, G., Ding, Y. & Bruner, S. D. Nat. Chem. Biol. 12, 973–979 (2016).
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Koehnke, J. The core of the matter. Nat Chem Biol 17, 1118–1119 (2021). https://doi.org/10.1038/s41589-021-00863-x
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DOI: https://doi.org/10.1038/s41589-021-00863-x