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BIOSYNTHESIS

The core of the matter

Graspetides are an important class of ribosomal natural products with potent bioactivities. New structural information provides insights into substrate recognition and catalysis, including a rare glimpse into the interactions between a tailoring enzyme and the core of the precursor peptide.

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Fig. 1: Substrate modifications and interactions of PsnB.

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Correspondence to Jesko Koehnke.

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Koehnke, J. The core of the matter. Nat Chem Biol 17, 1118–1119 (2021). https://doi.org/10.1038/s41589-021-00863-x

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