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Post-translational modification

Linking K29-Ub chains to biology

Nature Chemical Biology volume 17, pages 843–844 (2021)Cite this article

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Different ubiquitin chain types serve as distinct cellular signals. A new synthetic antigen-binding fragment, sAB-K29, specifically recognizes K29-linked diubiquitin and links K29 chains to proteotoxic stress and their accumulation in midbodies during mitosis.

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Fig. 1: New tool to study K29-linked ubiquitylation.

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Authors and Affiliations

  1. MRC Protein Phosphorylation and Ubiquitylation Unit, Sir James Black Centre, School of Life Sciences, University of Dundee, Dundee, Scotland, UK

    Sven M. Lange & Yogesh Kulathu

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  1. Sven M. Lange
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  2. Yogesh Kulathu
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Correspondence to Yogesh Kulathu.

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The authors declare no competing interests.

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Lange, S.M., Kulathu, Y. Linking K29-Ub chains to biology. Nat Chem Biol 17, 843–844 (2021). https://doi.org/10.1038/s41589-021-00833-3

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