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Undermodification cues division

Extracellular peptidoglycan-linked polysaccharide modifications mediate cell morphology, division, and autolysis in some Gram-positive bacterial pathogens. A new study shows that the degree and location of a specific modification controls peptidoglycan hydrolysis and placement of the axis of cell division.

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Fig. 1: Graphical summary of the modifications of extracellular peptidoglycan-linked polyrhamnose carbohydrate (SCC) in wild-type (left) and mutant (right) cells of S. mutans.


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This work was supported by NIH grant R35GM131767 (to M.E.W.).

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Correspondence to Malcolm E. Winkler.

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The author declares no competing interests.

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Winkler, M.E. Undermodification cues division. Nat Chem Biol 17, 841–843 (2021).

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